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Will CBD Work for You?

Why CBD Might Not Work For You

Not All CBD is Created Equal

CBD is a wonderful all-natural medicine. CBD is a fantastic alternative to addictive and dangerous pharmaceuticals.  It works wonderfully for hundreds of thousands of people.  CBD research shows that CBD is capable of easing many conditions.  However, CBD is NOT a miracle cure or 100% effective for everyone; nothing is.  CBD oil might NOT work for you.

That’s why we get upset when people say CBD oil doesn’t work. Period.  It just didn’t work for THEM.  If CBD doesn’t work for you, it could be the answer for a family member or friend! Let’s go into further detail and explore some reasons why CBD might not work for you.

Let’s start with the basics.  Not All CBD oil is created equal.

Brand & Dosage

If you’ve tried CBD and it was ineffective, don’t automatically assume that all CBD products are bad. Maybe you purchased a bad product, maybe you weren’t using enough, or it didn’t contain enough CBD, perhaps it didn’t contain CBD at all.

Knowing what’s in your CBD, where and how it’s grown, how it was extracted and 3rd party testing are important.

The first thing you should know – Never purchase CBD oil from a company that doesn’t use third-party lab testing. At present, it is an unregulated industry so a lot of low-standard oil gets through. Third party testing from a reputable lab removes most of the doubt about the reputation of the brand, in addition to showing the percentage of CBD in the product, other cannabinoids, heavy metals, and more.

In some cases, you’ll get companies that claim their bottles have 99% CBD but only contain much less.

  • Without lab results, how can you tell?
  • If you are using a quality brand, are you taking enough?
  • Are you using it every day?

Here are some examples of generic dosing recommendations. Keep in mind everyone is different and every body has different needs.

  • 2.5 – 20mg daily to alleviate chronic pain.
  • Up to 400mg a day for epilepsy.

Notice the different doses per condition and the large range? Always begin with a low dose, but keep increasing it until you feel an effect. If you go as far as 100mg a day for pain, and it isn’t working, perhaps CBD is not for you.


CBD works with the endocannabinoid system (ECS) and some of us are born with more endocannabinoids than others.  CBD oil works due to the way the body interacts with it.  If you have a genetic disorder for example, you could experience paranoia when using THC but CBD should help you.  If not, your genetics could  be to blame.

About 20% of Americans have a genetic mutation that increases the natural endocannabinoid level in the body.  If you’re lucky enough to have this mutation, you’ll feel less anxious than a normal person but conversely, since you have extra cannabinoids already, CBD may not prove effective. If you’d like to find out how your body would respond to weed, you can use a service such as 23andMe to predict how you’ll respond.


Men are generally larger than women and generally they need higher doses of CBD than women. If you’re a female, you’re naturally more sensitive to the cannabinoids in cannabis – including CBD. This means you are also more likely to benefit from pain relief.

Research also shows that THC works closely with estrogen, so cannabis is most powerful in women when estrogen levels are at their peak, during a menstrual cycle.  It is unclear if CBD is more effective during this period.

Biochemistry & Lifestyle

We’re all wired differently which means some people are simply more sensitive to CBD than others.  For example, have you ever wondered why one person can drink a six-pack of beer and feel okay, but someone else is on the floor after only two?   It is all about the endocannabinoid system. Factors such as genetics, stress, diet, and lifestyle impact how the ECS functions.

If CBD isn’t working for you, take a close look at your lifestyle, and pay particular attention to the amount of fatty acids in your diet. If your diet is low in fatty acids, especially omega-3, your ECS will not function at a high level. CBD is a form of fatty acid so if you’re already consuming a lot, cannabidiol will not be as effective as in someone who is lacking in fatty acids.

Also, if your CB2 receptors are stronger than the CB1 receptors, or vice versa, CBD will not be as effective because your biochemistry affects your endocannabinoid balance.  Nature endowed us with our own cannabinoids, so unless you have a deficiency of them or sluggish receptors, you may not need supplementation.

Physical Health

By now, it should be apparent that CBD works best in people with significant endocannabinoid gaps. If you’re in excellent shape with no real ailments, CBD oil won’t help you as much as if you had other conditions. Individuals with medical conditions have an altered biochemistry and when you consume CBD, it produces a number of chemical interactions in the body which work to restore internal homeostasis.

Psychological Health

CBD will be far more effective if you suffer from psychological conditions that are affecting your mental health.

In this instance, there is a chemical imbalance in the brain that is partially to blame for your mental issues. When you use CBD, the chemical balance could be restored which should make you feel a lot better.


Generally speaking, the more CBD you use, the greater your tolerance. So if you’ve used 20mg a day for a year,  or 50mg a day for five years,  it might not have the same effect as when using it for the first time.

Fortunately, there are ways to address the situation. One of the best methods of decreasing tolerance is to take a CBD break. Even a couple of weeks should be enough to restore disorder and ensure your body reacts positively to the ‘new’ stimuli.

Strains & The Entourage Effect

There are hundreds of cannabis strains and practically none of them have identical levels of THC, CBD or other cannabinoids. The best marijuana CBD strains include Charlotte’s Web, Harlequin, Cannatonic, and Canna-Tsu. While Charlotte’s Web has enormous amounts of CBD but minimal THC, Harlequin has more than enough THC to get you high.  If consuming marijuana is not legal in your state, consuming hemp based products is legal in all 50 states.  And the hemp plant generally contains much higher levels of CBD with minimal levels of THC.

CBD isolate works for hundreds of thousands of people all on it’s own, but if CBD is not effective for you when taken by itself as an isolate, the next step would be to try a broad-spectrum CBD product, without THC, or a full-spectrum CBD product that contains minimal levels of THC.  Some people need the “entourage effect,” which essentially means that CBD oil might work better for you when it contains other natural cannabis compounds like terpenes and flavonoids.

If CBD isolate, broad-spectrum or full-spectrum CBD do not work for you, marijuana might be the answer. Just make sure it’s legal in your state. And when all these natural medicinal alternatives have failed, unfortunatey, you may have no choice but to take pharmaceuticals.

Final Thoughts on CBD Oil’s Efficacy

If you’ve tried CBD and it was ineffective, don’t automatically assume that all CBD products are bad. Go through the list and see if anything applies to your situation. Perhaps you’ve purchased bad oil? Maybe your genetics or biochemistry means cannabinoids don’t work. Or, perhaps you’re simply not taking a strong enough dose.  Just keep in mind, if CBD doesn’t work for you, it could be a fantastic natural alternative and the answer for a family member or friend!

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