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CBD Isolate Study Overcomes Clinical Limitations

New-study-on-cbd-isolates

Study Finds CBD Isolates Overcome Clinical Efficacy Limitations of CBD Oil Extracts

Cannabidiol (CBD) isolates are suddenly getting a lot of attention in the scientific and medical communities and rave reviews by patients.

By now, most people are familiar with CBD extracts, which typically come in the form of an oral concentrate taken under the tongue.

Most CBD extracts on the market today contain up to 113 different cannabinoids plus other plant materials such as oils and other phytonutrients, known as ‘full-spectrum’ or ‘broad-spectrum.’

What sets CBD Isolate apart?

The additional purification processes they undergo to essentially “isolate” the CBD molecules in their purest form.

CBD isolate is a dry, crystalline form of CBD, purified to the extent that up to 99 percent of the oil and additional plant nutrients are removed.

CBD is Proving To Be an Effective Treatment for Many Ailments

While CBD is proving to be an effective treatment of inflammation, pain and a host symptoms correlating with neurological conditions such as multiple sclerosis or epilepsy, there are limitations on the immediacy and duration of its effectiveness, even at high doses, according to authors of a 2015 Israeli study.

The study, which charted efficacy over a 24-hour period, found:

  • Full-spectrum results follow a bell-shaped curve peaking at a 6-hour mark, regardless of the size of the dose.
  • Isolated CBD were more consistently effective over time and higher doses improved efficacy.

Highlights of Israeli Study

Abstract: Cannabidiol (CBD), a major constituent of Cannabis, has been shown to be a powerful anti‐in‐ flammatory and anti‐anxiety drug, without exerting a psychotropic effect. However, when given either intraperitoneally or orally as a purified product, a bell‐shaped dose‐response was observed, which limits its clinical use. In the present study, we have studied in mice the anti‐inflammatory and anti‐nociceptive activities of standardized plant extracts derived from the Cannabis sativa L., clone 202, which is highly enriched in CBD and hardly contains any psychoactive ingredients. In stark contrast to purified CBD, the clone 202 extract, when given either intraperitoneally or orally, provided a clear correlation between the anti‐inflammatory and anti‐nociceptive responses and the dose, with increasing responses upon increasing doses, which makes this plant medicine ideal for clinical uses. The clone 202 extract reduced zymosan‐induced paw swelling and pain in mice, and prevented TNFα production in vivo. It is likely that other components in the extract synergize with CBD to achieve the desired anti‐inflammatory action that may contribute to overcoming the bell‐shaped dose‐response of purified CBD. We therefore propose that Cannabis clone 202 (Avi‐ dekel) extract is superior over CBD for the treatment of inflammatory conditions.

Citation: Gallily, R., Yekhtin, Z. and Hanuš, L.O. (2015) Overcoming the Bell‐Shaped Dose‐Response of Can‐ nabidiol by Using Cannabis Extract Enriched in Cannabidiol. Pharmacology & Pharmacy, 6, 75‐85. http://dx.doi.org/10.4236/pp.2015.62010

Read Full Study

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Why CBD Isolate? Why Not?

Why CBD Isolate?

CBD is responsible for a large portion of the therapeutic qualities of the cannabis plant, but without psychotropic effects.  Those who are solely interested in the medicinal value of cannabis, may find CBD isolate to be an extremely appealing form of the product.  It’s not necessary to use THC with CBD for it’s effectiveness, which is why pharmaceuticals are isolating it. If you’re looking for a CBD rich product, with no THC, choose a CBD Isolate or broad spectrum with no THC.

RESTART CBD Isolate * 99% Pure CBD * No THC

Whether you are already a CBD enthusiast, or are simply curious about the potential benefits, you have undoubtedly noticed a diverse selection of CBD products available. CBD can be taken orally as a tincture, in a capsule, applied topically, vaped, and enjoyed in a variety of sweet treats.

CBD products are fairly new and quite exciting. That’s because cannabidiol (CBD) works directly with the messengers and receptors in your brain that keep your system in balance. CBD is not a medical treatment but is quickly growing in popularity as a beneficial dietary supplement.

You may have noticed that some products specify the inclusion of full-spectrum CBD extracts, while other products contain CBD isolate. You don’t need to worry. Both full-spectrum and CBD isolates are beneficial.

RESTART CBD uses only CBD isolate in our Signature Products (Replenish, Recover and Relax)  assuring that the products are THC Free.

Here’s Why.

In it’s isolate form, CBD is separated from all other cannabis compounds found in the original hemp plant. You could say that CBD isolate is purified CBD, everything else has been removed, leaving only the positive effects of the cannabidiol. While CBD isolate does not provide the full complexity of the hemp plant, there are several advantages to choosing a product made with CBD isolate. Some of those advantages include:

  • All trace amounts of THC have been removed.
  • More precise control over the amount of CBD in the final product.
  • No taste or odor to interfere with the formulation of CBD products.
  • Typically used in edibles and topical treatments for these reasons.

While some prefer knowing that they are getting the full-spectrum value of their CBD oil, there are many situations where a CBD isolate would be preferred over a full-spectrum product. Whether you choose a full-spectrum product, or an isolate is up to you and should be based on your specific reasons for pursuing the benefits of CBD.

After making your selection, you should know that it may take a bit of time before you find your best CBD serving. Everyone responds to CBD differently, and serving is based upon your desired effect rather than your weight. The suggested serving range of CBD for dietary supplementation is as broad as 5 – 100 mg of CBD per day. It is best to start with a lower daily dose and add more CBD each week until you achieve the effect you are looking for.

Note that CBD products can interact with some medications.  Consult with your doctor before taking CBD with other medications.


CBD is not a drug or a medical treatment, it is a dietary supplement, however FDA has approved a new prescription drug, EPIDIOLEX, the first cannabis-derived pharmaceutical to gain federal approval in the U.S.

EPIDIOLEX (Pharmaceutical)

EPIDIOLEX contains CBD isolate which is also found in a number of nutraceutical hemp products. Up until now, all forms of CBD (with exception to Farm Bill Compliant hemp derived CBD) have been classified as a Schedule I drug. Although we can’t be certain how the FDA’s approval will affect the cannabis industry, we can offer our thoughts. So, let’s look at the facts.

CBD isolate (the active ingredient in EPIDIOLEX) is a refined version of full spectrum hemp oil containing only pure CBD.

Based on years of research, EPIDIOLEX has proven benefits in treating two rare forms of epilepsy.
    • Treatment for: Lennox-Gastaut Syndrome; Dravet Syndrome.
    • Active ingredient: cannabidiol.
  • Inactive ingredients: dehydrated alcohol, sesame seed oil, strawberry flavor, and sucralose Epidiolex does not contain gluten (wheat, barley or rye).
  • Cost for the uninsured: About $32,500 per year, or just over $2,700 per month, depending upon the weight of the patient and the dosing. That’s in line with other prescription drugs used to treat the same afflictions.
  • Cost for USA Insured patients: Up to $200 per month under a recent pricing announcement from the maker, GW Pharmaceuticals.

———————-Epidiolex Dosage and Administration———————-­

  • EPIDIOLEX is to be administered orally.
  • The recommended starting dosage is 2.5 mg/kg taken twice daily(5 mg/kg/day). After one week, the dosage can be increased to a maintenance dosage of 5 mg/kg twice daily (10 mg/kg/day).
  • EPIDIOLEX can be increased up to a maximum recommended maintenance dosage of 10 mg/kg twice daily (20 mg/kg/day).
  • Dosage adjustment is recommended for patients with moderate or severe hepatic impairment.
  • Dosage Strengths: Oral solution: 100mg/ml

RESTART CBD Isolate     

Although RESTART CBD has not been granted federal approval like EPIDIOLEX, RESTART CBD is a pure, CBD isolate product.

This product is not intended to diagnose, treat, cure or prevent any disease. However, many studies have been conducted for a variety of ailments.

  • Treatment for: Over all wellness, recovery and relaxation plus a host of CBD Benefits.
  • Active ingredient: cannabidiol
  • Inactive ingredients: Organic MCT Coconut oil.  Nothing else. (no alcohol, no artificial flavors, no sucralose)
  • Cost: $75-125 per 30ml bottle
  • RESTART REPLENISH CBD 600mg/30ml (20mg CBD per 1mL)
  • RESTART RECOVER CBD 900mg/30ml (30mg CBD per 1mL)
  • RESTART RELAX CBD 1200mg/30ml (40mg CBD per 1mL)
  • RESTART REPAIR CBD 1800mg/30ml (60mg CBD per 1mL)

The Bottom Line

No prescription is necessary to purchase of CBD derived from industrial hemp.  At least not at this time.  CBD is an incredible compound worthy of the medical field’s and government’s respect.  While it may be beneficially isolated from the rest of the cannabis compounds, you may also find it beneficial to work in tandem with THC and other cannabinoids.

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